cees dekker - An Overview

‘The 2nd is nanopores, which happens to be our oldest line of research and that has now triggered DNA sequencers according to nanopores. We pull unique DNA strands via a nanopore and might then examine off the nucleotide sequence. Really not too long ago, we even managed to go through out just one protein for the first time applying This system. But this line of investigation is not merely about building tools, but also about serious Organic inquiries.

Human Rad51 filaments on double- and solitary-stranded DNA: correlating regular and irregular kinds with recombination functionality.

, Groningen researchers present the outcomes of their attempts to produce labs far more sustainable and supply tricks for other labs. 

Nanofabrication of electrodes with sub-five nm spacing for transport experiments on solitary molecules and metal clusters

Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart design and style in 2005. (nl)

SMC complexes can pass Actual physical roadblocks larger than their ring dimensions, indicating a nontopological mechanism for DNA loop extrusion

All parameters have been precisely the same for every panel During this video, except for the Preliminary placement in the 6hb rod (demonstrated in blue) to the nanopore. Simulations that terminated early due to translocation from the rod with the pore are marked by a grey track record.

Nanopores depict a chic and adaptable Resource to evaluate solitary molecules. We analysis novel detection modes with reliable-condition nanopores and also a variety of strategies to measure proteins with nanopores. Assignments ceesdekker.net encompass the next:

Knowledge essential procedures regulating the spatial and dynamic organisation of your DNA in live cells.

There was 1 dilemma nevertheless — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule level, conducting polymers had been truly not these terrific conductors, which was alternatively disappointing. We thus broadened our see to try to locate a lot more promising molecules.

An built-in microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes

Character Physics thanks the nameless reviewers for their contribution to the peer critique of this work.

2008, very first observation of protein-coated DNA translocation by way of nanopores; solved the origin on the electrophoretic power on DNA in nanopores; identified a substantial velocity boost of microtubules in electric fields; found an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid

The biophysicist from Delft – who has actually been The most cited scientists in the Netherlands For some time – normally takes his duty to add on the explanation and popularisation of his do the job for the border of physics and biology incredibly seriously and consistently appears within the media; Otherwise to speak about his work, then about the connection between science and his Christian religion.